About Queen's University
Queen’s University is the Canadian research intensive university with a transformative student learning experience. Here the employment experience is as diverse as it is interesting. We have opportunities in multiple areas of globally recognized research, faculty administration, engineering & construction, athletics & recreation, power generation, corporate shared services, and many more.
We are committed to employment equity and diversity in the workplace and welcome applications from individuals from equity seeking groups such as women, racialized/visible minorities, Indigenous/Aboriginal peoples, persons with a disability, persons who identify in the LGBTQ+ community and others who reflect the diversity of Canadian society.
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The goal of the laboratory’s research is to give cancer patients more quality time by harnessing the immune system to fight cancer. The lab uses a variety of molecular pathology techniques to study human tumor tissue and investigate the regulation of immune responses to cancer. The goal is to identify tissue-based biomarkers that can be validated in clinical trials and will ultimately allow each patient to get the best available therapy at any stage of disease. The research team will achieve these goals through the fearless pursuit of excellence in a supportive and diverse setting.
Reporting to the Principal Investigator (PI), the Research Technologist will assist with the ongoing experimental and administrative activities of the laboratory. The incumbent will be highly motivated and eager to learn new techniques. Responsibilities will include coordinating equipment/ reagent acquisition and purchasing, record keeping of grant budgets, specimen tracking, assisting in the development of standard operating procedures for laboratory techniques (including immunohistochemistry [IHC], multiplex immunofluorescence [mIF], in-situ hybridization [ISH], and isolation of DNA and RNA from formalin fixed paraffin embedded [FFPE] tissue) image acquisition using the Vectra Polaris microscope and related lab procedures, as well as maintaining accurate records of experimental methods and results and data-interpretation. Additional responsibilities will include training of new lab members, guiding others in safe use of lab equipment and maintaining regulatory compliance for all lab operations by keeping up-to-date documentation for biohazard/biosafety and ethics mandates. As this position supports research leading to clinical diagnostic tests, the Research Coordinator must clearly understand the importance of quality work as it relates to the impact on patient treatment.
Requests, tracks, and organizes pathology specimens as required for each project/experiment; the incumbent will need to be familiar with surgical pathology and lab procedures for requesting and cutting specimens.
Plans and executes experiments to optimize immunohistochemistry staining for markers of interest and build multiplex immunofluorescence panels. This would incorporate evaluating/interpreting test results, utilizing detailed knowledge of research laboratory procedures and practices.
Perform some experimental design and adapt or modify protocols as needed to meet the goals of the research project
Participates in the development, implementation and record keeping of standard operating procedures and safety protocols under quality assurance guidelines.
Resolves IHC/ISH staining problems, including reagent preparation, dilutions, expiration dates, and other procedural functions.
Provides organizational orientation and training specific to the research activities of the laboratory to new research staff and students. Provides support in safe use of lab equipment and procedures such as staining, and scanning tissue slides.
Co-ordinate a safe and clean work environment. This includes cleanliness and organization of lab workbenches, safe disposal of hazardous waste and providing lab-specific safety training to others.
Ensures that the lab knowledge is properly documented and prepare periodic reports on workflow, as needed.
Schedule and conduct lab meetings or team meetings as necessary. Coordinate with undergraduate and graduate students to guide them in their thesis/project work.
Monitors inventory levels and orders materials and supplies in accordance with established policies and procedures as required for experimental protocols.
Order reagents and equipment for the lab in accordance with health and safety regulations. This will include organizing, purchasing, keeping track of invoices inventorying and accounting for purchases.
Assists with the development and administration of laboratory budgets and performs other related administrative and financial duties for the Principal Investigator and research lab.
Performs administrative procedures in support of the lab. This includes applying for funding for summer students.
Assists the PI in grant writing and funding applications as well as creating budgets and yearly reporting on expenditures to funding agencies.
Liaises and facilitates communication with internal contacts and external agencies to gather information, coordinate meetings and serve as a contact point for all non-academic/sales inquiries.
Completes annual university biohazard/universal precaution/radiation safety training, as appropriate, as well as other required online and in-person trainings and compliance requirements.
Undertakes additional duties as assigned in support of the PI/research lab.
Three-year post-secondary program in biotechnology, immunology, molecular biology, or a relevant life sciences field
Minimum 2 years of lab management experience in health sciences research laboratory or similar setting
Knowledge of laboratory procedures including surgical pathology, histology (e.g., tissue preparation, staining, and sectioning, immunohistochemistry, and immunofluorescence staining), RNA extraction, qPRC, and in-situ hybridization.
Knowledge of Good Clinical Practice (GCP) and Good Lab Practices (GLP).
Consideration may be given to an equivalent combination of education and experience.
Respect diversity and promote inclusion in the workplace.
Willingness to learn and perfect new techniques.
Ability to coordinate workflow and use of personal judgement in applying scientific techniques to obtain accurate and relevant experimental results.
Ability to handle hazardous materials, safely operate equipment, and prepare solutions or samples appropriately. Foresight in predicting problems and altering procedures to minimize risk, as required.
Ability to work independently and as a team member to complete tasks with little or no supervision. Demonstrated ability to manage multiple priorities and meet deadlines.
Critical observational skills with the ability to perform careful measurements and interpret experimental results.
Possess technical/scientific communication skills, both written and verbal.
Organizational, problem-solving, and analytical skills. Judgement in choosing best protocol or adapting procedures to meet changing needs.
Possesses knowledge of microscopy to evaluate routine IHC/ISH control slides that accompany each IHC/ISH run.
Will be adept at database management for each research project/experiment.
Familiar with best practices for sterile technique, reagent preparation and storage, and universal safety precautions to protect self and co-workers from biohazardous materials, including blood or tissue-borne pathogens.
Experience with automated IHC staining and digital image analysis are an asset.
Determine what supplies, equipment, safety and operating procedures are required for functioning of the research lab and how to most optimally acquire, allocate and utilize laboratory space and resources.
Decide how to deal with experimental error and problems, such as equipment breakdown by minimizing impact on the results and decide when problem is complex enough to contact senior staff.
Make decisions regarding the alteration of procedures or protocols, as the need arises during an experiment.
Determine when it is necessary to seek advice or direction from supervisor with respect to experimental procedure, operation of equipment, etc.
Direct research inquiries to the proper person or supply the answer if appropriate.
Employment Equity and Accessibility Statement
The University invites applications from all qualified individuals. Queen’s is committed to employment equity and diversity in the workplace and welcomes applications from women, visible minorities, Aboriginal Peoples, persons with disabilities, and persons of any sexual orientation or gender identity. In accordance with Canadian Immigration requirements, priority will be given to Canadian citizens and permanent residents.
The University provides support in its recruitment processes to applicants with disabilities, including accommodation that takes into account an applicant's accessibility needs. Candidates requiring accommodation during the recruitment process are asked to contact Human Resources at firstname.lastname@example.org.