Technical Officer, In Vivo Pharmacology

National Research Council Canada - Ottawa, ON (30+ days ago)

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Help bring research to life and drive your career forward with the National Research Council of Canada (NRC), Canada's largest research and technology organization.

We are looking for a Technical Officer to support our Human Health Therapeutics Research center. The candidate would be someone who shares our core values of Integrity, Excellence, Respect and Creativity.

In the past few years, development of bio-therapeutics to treat various diseases, including cancer and neurodegenerative disorders, has taken the center stage. Significant progress is being made in the design, engineering and development of novel therapeutics. Treating neurodegenerative diseases is particularly challenging because of poor delivery of bio-therapeutics to the brain due to the presence of the blood-brain barrier (BBB). You will have a unique opportunity to participate in a multi-team, multi-site collaborative research effort to develop novel (BBB) permeable CNS bio-therapeutics. Responsibilities will include providing technical support services in the design, planning, preparation, execution, analysis and documentation of experiments, and preparation of reports for clients.

Screening Criteria

Applicants must demonstrate within the content of their application that they meet the following screening criteria in order to be given further consideration as candidates:


Bachelors’ degree in Biochemistry, Biotechnology, or relevant related discipline.

Other relevant education in Life Science combined with significant industrial experience may be also considered.

For information on certificates and diplomas issued abroad, please see Degree equivalency


Experience in biochemical and immunochemical assays such as ELISA, Western blot, immunocytochemistry and immunohistochemistry

Experience in preparing and culturing primary neuronal cells, and in culturing established cell lines for cell-based and other assays

Experience in animal studies (in vivo studies), including transcardial perfusion, tissue collection and dissection, and cryostat sectioning

Experience in microscopy imaging techniques (phase contrast, fluorescence etc)

Experience in supporting the development of Bioanalytics for bio-therapeutics

The following is considered an important asset towards consideration for the position:

Experience in working on Industrial Project(s) with clearly defined milestones and time-bound deliverables

Experience in working in a multidisciplinary environment interacting with personnel from various teams
Condition of Employment

Reliability Status

Language requirements


Information on language requirements and self-assessment tests

Assessment Criteria

Candidates will be assessed on the basis of the following criteria:

Technical Competencies

Working knowledge of safe handling procedures for biological samples, particularly blood (serum), cerebrospinal fluid (CSF), experimental animal tissues, synthetic and recombinant proteins, including physical manipulation, proper storage conditions and working under sterile environment.

Working knowledge of biochemical and immunological methods for the characterization of biologics such as SDS-PAGE, Western blot, ELISA, Spectroscopy (Absorbance, fluorescence) and imaging.

Working knowledge of tissue culture techniques

Ability to prepare and maintain primary neuronal cells

Ability to support biochemical and functional characterization blood-brain barrier crossing bio-therapeutics in vitro and in vivo by executing and properly documenting experimental methodologies and results.
Behavioural Competencies
Research Technician/Technologist - Results orientation (Level 2)
Research Technician/Technologist - Initiative (Level 2)
Research Technician/Technologist - Communication (Level 2)
Research Technician/Technologist - Teamwork (Level 2)
Competency Profile(s)

For this position, the NRC will evaluate candidates using the following competency profile(s): Research Technician/Technologist


Relocation assistance will be determined in accordance with the NRC's directives.

Salary Range

From $56,730 to $77,692 per annum.


A pre-qualified list may be established for similar positions for a one year period.

NRC employees enjoy a wide-range of benefits including comprehensive health and dental plans, pension and insurance plans, vacation and other leave entitlements.

Preference will be given to Canadian Citizens and Permanent Residents of Canada. Please include citizenship information in your application.

The incumbent must adhere to safe workplace practices at all times.

Please direct your questions, with the requisition number (8601) to:


Telephone: 613-949-7685

Closing Date: 02 February 2020 - 23:59 Eastern Time